Buy Amoxicillin online
Brand names: Amoxil, Trimox, Moxatag, Wymox, Moxilin, Biomox, Actimoxi, Alphamox, Amoxicot, Amocla, Tycil, Dispermox
Active ingredient: Amoxicillin
Amoxicillin - broad-spectrum antibiotic from the group of semi-synthetic penicillins, with a broad spectrum of action. Effect of amoxicillin sets very quickly. Like other penicillin antibiotics, it inhibits cell wall synthesis.
Amoxicillin and bactericidal activity against Gram-positive spinners (Staphylococcus spp., Streptococcus pneumonia, Streptococcus group A, B, C, G, H, I, M); Gram-negative cocci (Neisseria meningitides, N. gonorrhea); Gram-negative rods (Escherichia coli, Shigella spp., Klebsiella spp., Proteus mirabilis, Salmonella, Campilobacter, Haemophilus influenzae, Bordetella pertussis, Chlamydia).
Amoxicillin is active against all microorganisms sensitive to penicillin G: Erysipelothrix rhysiopathiae, Corynebacterium, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pastereulla multocida, Listeria, Spirochaeta (Leptospira, Treponema, Borrelia) and others., As well as a variety of anaerobic microorganisms.
To amoxicillin-resistant strains of microorganisms that produce beta-lactamase. Amoxicillin is acid and therefore is effective when administered orally.
After oral administration, amoxicillin is almost completely absorbed from the gastrointestinal tract. Eating does not affect the absorption of amoxicillin. The maximum concentration of amoxicillin determined in blood plasma within 1-2 hours following ingestion, and is about 7-8 mg / ml.
The plasma protein binds Amoxicillin 20%. Amoxicillin is widely distributed in tissues and body fluids: high concentrations are achieved in the lungs, kidneys, mucous membranes of the respiratory tract, urine, plasma, bronchial secretions, pleural and peritoneal fluid. When the normal function of the liver has a high concentration of the drug in the bile.
Half-life of amoxicillin in patients with normal renal function is 1 - 2 hours. Up to 60% of the dose is excreted in the urine within 6 hours (mostly unchanged), some of the excreted through the gastrointestinal tract and lungs. If the kidney function is reduced renal and extrarenal clearance.
Bacterial infections caused by pathogens susceptible to amoxicillin:
Respiratory tract infections:
upper respiratory tract infections and upper respiratory tract, such as tonsillitis, acute otitis media, pharyngitis, sinusitis;
lower respiratory tract infections such as acute and chronic bronchitis, pneumonia, lung abscess, pertussis (the incubation period and the initial stage);
Infections of genitourinary organs:
acute and chronic pyelonephritis, pyelitis, prostatitis, epididymitis; cystitis, urethritis, asymptomatic bacteriuria during pregnancy; uncomplicated gonorrhea;
septic abortion, adnexitis, endometritis, etc..
Infections of the gastrointestinal tract:
typhoid, paratyphoid, especially complicated by septicemia (in combination with an aminoglycoside); carriers of salmonella; shigellosis; biliary tract infections (cholangitis, cholecystitis).
Combination therapy of gastritis and peptic ulcer disease (in combination with omeprazole, metronidazole):
in the acute phase, gastric ulcer and duodenal ulcer; in the acute phase, associated with Helicobacter pylori.
Infections of the skin and soft tissues. Leptospirosis. Acute and latent listeriosis. Lyme disease (borreliosis).
If you do not want to parenteral therapy, Amoxicillin is also active in the following conditions: short-term (24 - 48 hours), but preventive therapy during surgery (eg, oral tissues); infective endocarditis, e.g., enterococcal (alone or in combination with aminoglycosides); bacterial meningitis (depending on the determination result of sensitivity, especially in children); septicemia caused by microorganisms sensitive to amoxicillin.
In the treatment of infections caused by microorganisms with proven susceptibility to penicillin G, preference should be given to last drug.
Dosage and administration:
Inside. Wash down with plenty of fluids. Dosage depends on the sensitivity and the localization of the infectious process. In general, the total daily dose should be divided into 2 (3-4) reception. Children under the age of 10, it is desirable to prescribe a drug as a suspension. The suspension was prepared by adding the dry matter boiled water at room temperature and subsequent stirring.
Dosages for children, calculated per kg body weight, should not exceed the maximum dosage for adults.
Amoxicillin is highly effective and very well absorbed, so even severe infections amenable to oral therapy. The course of treatment is 5-14 days.
Hypersensitivity to penicillin antibiotics; infectious mononucleosis, lymphatic leukemia (increased risk of side effects).
In patients with hypersensitivity to cephalosporins, carbapenems should consider the possibility of cross-allergy.
In severe infections of the gastrointestinal tract, accompanied by constant diarrhea or vomiting should not be given amoxicillin inside because of the possibility of poor absorption.
The use of antibiotics is ineffective in the treatment of acute respiratory viral infections.
Particular caution should be observed in patients with allergic diathesis or bronchial asthma and hay fever (hay fever), diseases of the digestive tract in history (especially colitis associated with antibiotics).
Use during pregnancy and lactation:
Use of the drug in pregnant women is possible only under strict health reasons, under the supervision of a physician.
Data on the possible embryotoxic, teratogenic or mutagenic action while taking amoxicillin during pregnancy are at present no. Amoxicillin passes into breast milk. For the period of the course breastfeeding is possible.
In some cases, hypersensitivity, allergic reactions: urticaria, angioedema, erythema, rhinitis, conjunctivitis; rarely - fever, joint pain, interstitial nephritis, eosinophilia; extremely rare - anaphylactic shock, erythema multiforme, exfoliative dermatitis, a reaction similar to serum sickness.
May cause headache, fatigue, glossitis, stomatitis; haematological disorders: thrombocytopenia, agranulocytosis, leukopenia.
Gastrointestinal: diarrhea, nausea, vomiting, and may sometimes be a pain in the abdomen. Due to better absorption of amoxicillin, however, they are less common than with ampitsiillina. When the manifestation of diarrhea during treatment should consider the possibility of pseudomembranous colitis.
In extremely rare cases of superinfection (especially in patients with chronic diseases and the low resistance of the organism), dysbiosis, candidiasis.
In patients treated for typhoid fever, leptospirosis, or syphilis may develop Jarisch-Gerkskheymera caused lysis of bacteria.
As with all penicillins, whose concentration in plasma reaches high levels in patients with epilepsy and meningitis and decreased kidney function increased risk of neurotoxic complications (convulsions).
In some cases, there was a transient slight increase of aminotransferases (ALT and ALT) in serum.
Special instructions and precautions:
Caution should be exercised in the appointment of the drug to patients who are prone to allergic reactions (urticaria, hay fever). Patients should be aware of the possibility of allergic reactions and report them to your doctor. In the case of allergic reactions should eliminate the drug and treated with antihistamines and corticosteroids. When the maculopapular rash treatment should be discontinued.
Patients with cholangitis or cholecystitis antibiotics can be administered only under mild course of disease and in the absence of cholestasis. With prolonged use of high doses of the drug should be monitored liver function tests; produce urine and to determine renal function in patients with kidney disease.
It is advisable to determine the dynamics of the number of blood cells to detect antibody responses of the hematopoietic system and hemolytic anemia.
Long-term treatment should consider the possibility of excessive growth of resistant bacteria and fungi. When the secondary infections prescribe appropriate therapy. With the continuing severe diarrhea should be suspected pseudomembranous colitis caused by antibiotics (watery feces mixed with blood and mucus; dull common or colicky abdominal pain, fever, and sometimes tenesmus), which may pose a threat to the life of the patient. In such cases it is advisable to Amoxicillin immediately withdrawn and specific with respect to the pathogen treatment (eg, vancomycin, orally). Means of reducing the motility of the gastrointestinal tract, are contraindicated.
Before treatment of gonorrhea in patients with suspected primary syphilitic lesions is necessary to conduct a study in the dark field. All other patients with suspected concomitant syphilis serology should be done over time for at least 4 months.
Treatment is required to continue 48-72 hours after the disappearance of clinical signs of disease.
Patients with severe renal insufficiency (creatinine clearance 15-40) reduce single dose or increase the interval between doses of the drug up to 12 hours. When anuria dose should not exceed 2 grams per day.
During therapy are essential if adequate fluid intake and maintenance of adequate diuresis.
Diabetics should be aware that the drug may contain sugar (see. "Composition").
Non-enzymatic tests used to detect glucose in blood, may be false positives. Amoxicillin may also affect the results of the determination of urobilinogen.