Buy Augmentin online

Brand names: Augmentin, Augmentin ES-600, Augmentin XR
Active ingredient: Amoxicillin Clavulanate

Augmentin - antibiotic consists of amoxicillin and clavulanate. Amoxicillin - semisynthetic penicillin antibiotic with a broad spectrum of antibacterial activity against many Gram-positive and Gram-negative microorganisms. Amoxicillin is susceptible to the action of beta-lactamases, and disintegrates under its influence, therefore the spectrum of activity of amoxicillin does not include organisms that synthesize the enzyme. Clavulanate is a beta-lactam structure similar to penicillin, but also has the ability to inactivate beta-lactamase enzymes produced by microorganisms resistant to penicillins and cephalosporins. In particular, it has potent activity against important from a clinical point of view, the plasmid beta-lactamases, which are often responsible for the occurrence of cross-resistance to antibiotics. The presence of clavulanate in the Augmentin protects amoxicillin from the decay under the effect of beta-lactamase enzymes and expands the range of antibacterial activity of amoxycillin, including a plurality of microorganisms resistant to amoxicillin and other penicillins and cephalosporins. Thus, Augmentin possesses antibiotic properties, and broad-spectrum beta-lactamase inhibitor. Augmentin has bactericidal activity against a broad spectrum of microorganisms.

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Pharmacokinetics. Absorption

Both components of Augmentin (amoxicillin and clavulanate) is completely soluble in aqueous p-tures at physiological pH. Both components are well and rapidly absorbed upon oral administration. Absorption of Augmentin is improved by its reception in the beginning of the meal.


When applying inwardly therapeutic concentrations of amoxicillin and clavulanate are determined in tissue and interstitial fluid. Therapeutic concentrations of both substances detected in the gall bladder, abdominal tissue, skin, fat and muscle tissue, as well as in the synovial and peritoneal fluids, bile and pus. Amoxicillin and clavulanate is weakly bound to plasma proteins; investigations have established that the performance binding proteins constitute 25% of clavulanate and amoxicillin 18% of their total concentration in the blood plasma. In studies conducted on animals has not been established cumulation of any of these components in any organ.

Amoxicillin, like other penicillins, passes into breast milk. Trace quantities of clavulanate is also detected in breast milk. The study of reproductive function in animals have shown that amoxicillin and clavulanate can penetrate the placental barrier. However, do not reveal any information concerning the violation of reproductive function or harmful effects on the fetus.


medication is for temporary treatment of bacterial infections caused by sensitive microorganisms: upper respiratory tract infection (including upper respiratory tract infections), including recurrent tonsillitis, sinusitis, otitis media;

lower respiratory tract infections, including chronic bronchitis exacerbation, lobar pneumonia and bronchopneumonia;
urinary tract infections, including cystitis, urethritis, pyelonephritis;
infections of skin and soft tissue, including burns, abscesses, cellulitis, wound infections, animal bites;
bone and joint infections, including osteomyelitis;
other infections, including septic abortion, puerperal sepsis, intra-abdominal sepsis;
dental infections, including dentoalveolar abscesses.

The use of Augmentin tablets 1 g (875/125 mg) is also shown in the infection of female genital mutilation and gonorrhea.

Application Augmentin 1000/200 mg (in injectable form) is also shown in the infection of female genital mutilation and gonorrhea, for the prevention of infectious complications during surgery, with most types of surgery of the digestive tract, pelvic, head and neck, heart, kidney, when joint replacement surgery and bile ducts.

Infections caused by susceptible microorganisms to amoxicillin, augmentin effectively treated, given the content of amoxicillin. Mixed infections caused by not susceptible to amoxicillin in combination with microorganisms susceptible to Augmentin microorganisms - beta-lactamase producers can thus treated Augmentin.

Augmentin ES: treatment of bacterial infections in children caused by susceptible microorganisms Augmentin: upper respiratory tract infections (including ENT organs), including recurrent or persistent otitis media (pediatric patients are usually treated with antibiotic treatment of otitis media for at least 3 months or younger than 2 years of age or attending kindergartens); tonsillopharyngitis or sinusitis; lower respiratory tract infections, including pneumonia and lobar; infections of skin and soft tissues.


Augmentin (BD) 625 mg tablets (500/125 mg) for the treatment of infections of mild to moderate severity in adults and children over 12 years: 1 tablet Augmentin (BD) 2 times a day. In severe infections (including chronic and recurrent urinary tract infections and bronchopulmonary infections) 1-2 tablets prescribed Augmentin (BD) 3 times a day. Recommended dosing for dentoalveolar abscesses - 1 tablet 2 times a day for 5 days.


Augmentin tablets of 1 g (875/125 mg) Dosage depends on the age and body weight of the patient, renal function, the severity of the infection. The dose for the treatment of infections mild to moderate severity in adults and children over the age of 12 years: 1 tablet Augmentin 875/125 mg 2 times a day. In severe infections (including chronic and recurrent urinary tract infections and bronchopulmonary infections) - 1 tablet Augmentin 3 times a day. Augmentin tablets 1 g is not recommended for children under the age of 12 years.

Dosing with impaired renal function: Augmentin tablets 1 g (875/125 mg) is used only in patients with creatinine clearance> 30 ml / min. In renal insufficiency with creatinine clearance <30 mL / min Augmentin 875/125 mg is not applicable.

Dosing with abnormal liver function: should be used with caution, it is necessary to conduct regular monitoring of liver function. Data regarding dosing recommendations are not enough.

Dosing in elderly patients: a dose adjustment in elderly patients is not necessary; if necessary adjusting the dose depending on renal function. In order to reduce the undesirable effects on gastrointestinal drug should be taken at the beginning of the meal, while improving the absorption of Augmentin, treatment should not continue for more than 14 days without any assessment of the patient. Treatment can begin parenterally, then continue orally.

Augmentin suspension was 228.5 mg / 5 ml Recommended daily dose: 25 / 3.6 mg / kg / day for infections of mild to moderate severity (upper respiratory tract infection, such as recurrent tonsillitis, respiratory tract infections, skin and soft tissue ); 45 / 6.4 mg / kg / day in the treatment of more severe infections (infections of upper respiratory tract, such as otitis media and sinusitis, respiratory tract infections, such as pneumonia and urinary tract infection).


Maybe accompanied by symptoms in the digestive tract and disorders of water and electrolyte balance. Treatment is symptomatic, the correction of fluid and electrolyte disturbances. Crystalluria can occur, which in some cases leading to renal failure. There are reports of precipitation of amoxicillin in the urinary catheter when used in the I / Augmentin in high doses, so you should regularly check its patency. Augmentin can be removed from the blood during hemodialysis.