Buy Clonidine online
Brand names: Catapres, Clophelin, Kapvay, Nexiclon
Active ingredient: Clonidine
Clonidine - a antihypertensive drug. The effect of which is shown centrally. This means that it has no impact on peripheral arteries, and in the central nervous system, namely, at its sympathetic part. Clonidine stimulates alpha-receptors in the brain. The result of this is to reduce stimulation of the sympathetic innervation of blood vessels, which leads to a decrease of vascular resistance. Clonidine acts expanding peripheral blood vessels throughout the body. Clonidine may be second-line drugs in the treatment of hypertension when other drugs are ineffective in reducing blood pressure.
Increases renal blood flow; raising the tone of cerebral blood vessels, reduces cerebral blood flow; has a strong sedative effect.
The duration of the therapeutic effect - 6-12 h.
With instillation into the conjunctival sac there is a reduction in intraocular pressure due to local stimulating action, which resulted in reduced production of intraocular fluid and somewhat improves its flow, as well as due to the weakening of the sympathetic tone due to the central effects of the active substance, a part of which was subjected to resorption.
If ingestion is well absorbed from the gastrointestinal tract, Cmax in plasma is reached after 2-4 hours. Binding proteins - 20-40%. Metabolized in the liver about 50% of the absorbed dose. T1 / 2, with normal renal function - 12-16 hours, if the kidney function - up to 41 hours. Excreted by the kidneys - 40-60% unchanged through the intestines - 20%.
Hypertensive crisis, arterial hypertension, primary open-angle glaucoma - as monotherapy or in combination with other drugs that reduce intraocular pressure (eye drops).
Hypotension, marked cerebral atherosclerosis, peripheral artery disease, severe sinus bradycardia, sick sinus syndrome, AV-block II and III degree, cardiogenic shock, depression (including in the anamnesis), the simultaneous use of tricyclic antidepressants, the simultaneous use of ethanol and other means of providing a depressing effect on the central nervous system, pregnancy, lactation, hypersensitivity to clonidine.
On the part of the cardiovascular system: rarely - edema, bradycardia; at / in the introduction possible orthostatic hypotension.
From the digestive system: reduction of gastric secretion, dry mouth; rarely - constipation.
CNS and peripheral nervous system: fatigue, sleepiness, slowing of mental and motor responses; rarely - nervousness, anxiety, depression, dizziness, paresthesias.
Reproductive system: rarely - decreased libido, impotence.
Allergic reactions: skin rash, itching.
Other: nasal congestion.
Local reactions: dryness of the conjunctiva, itching, or burning sensation in the eyes.
Patients receiving beta-blockers, in the case of abrupt withdrawal of clonidine may sharp increase in blood pressure. It is believed that this is due to increased levels of catecholamines in the blood circulation and strengthening of their vasoconstrictor action.
With simultaneous use of hormonal contraceptives for oral administration may increase sedation clonidine.
With simultaneous use of tricyclic antidepressants decreases antihypertensive effect of clonidine. With the simultaneous use with clonidine may increase the duration of action of vecuronium. While the use of verapamil has reported the development of heart block in a patient with hypertension.
Suggest that clonidine suppresses increased production of catecholamines which arises due to hypoglycaemia, and consequently the symptoms of hypoglycemia (tachycardia, palpitations, sweating), which due to the influence of catecholamines. Furthermore, there are reports that clonidine increases blood glucose, apparently due to a decrease in insulin secretion. This must be taken into consideration while applying insulin.
In the transition from clonidine on captopril antihypertensive effect last develops gradually. In the case of abrupt withdrawal of clonidine in patients receiving captopril, blood pressure may rise rapidly.
There are reports of a decrease in the effectiveness of levodopa and piribedil in patients with Parkinson's disease.
While the use of prazosin may change antihypertensive effect of clonidine.
With simultaneous use of propranolol, atenolol develops additive antihypertensive effect, sedation, dry mouth.
While the use of cyclosporine has reported increase in the concentration of cyclosporine in the blood plasma.
Dosage and administration:
Set individually. Initial dose - 37.5-75 mg 3 times / day. If necessary the dose gradually increased to an average daily dose of 900 micrograms. The course of treatment is on average 1-2 months.
When the / m or / in a single dose of 150 micrograms.
Maximum dose: ingestion single dose - 300 mg daily dose - 2.4 mg.
For use in ophthalmology: drip into the conjunctival sac 2-4 times / day. Treatment is initiated with the appointment of 0.25% solution. In case of insufficient reduction of the intraocular pressure using 0.5% solution. With the development of side effects associated with the use of 0.25% solution, administered 0.125% solution.