Buy Lisinopril online
Brand names: Lisinopril
Active ingredient: Hydrochlorothiazide
Lisinopril - thiazide diuretics medium strength. It is used for hypertension, edematous syndrome of different genesis, control polyuria primarily for nephrogenic diabetes insipidus, preventing the formation of stones in the urinary tract in predisposed patients. Hypertension; edema in congestive heart failure, liver cirrhosis with ascites; treatment with corticosteroids and estrogens; some renal impairment (including nephrotic syndrome, acute glomerulonephritis, chronic renal failure); central and nephrogenic diabetes insipidus, glaucoma (subcompensated form). Lisinopril is also used to prevent the formation of calcium kidney stones, in patients with idiopathic hypercalciuria.
After oral administration, 60-80% of Lisinopril is rapidly absorbed from the digestive tract. The diuretic effect after 2 hours, reaching a peak after 4 hours and continued until 12 hours.
Approximately 95% of Lisinopril is excreted unchanged by the kidneys almost completely. The half-life is 5,6-14,8 hours. Small amounts of the drug are excreted in the bile.
Lisinopril crosses the placental barrier, gets into breast milk.
Anuria or severe renal dysfunction, severe gout and diabetes, abnormal liver function, hypercalcemia, systemic lupus erythematosus, a history of pancreatitis, hypersensitivity to thiazide diuretics or other sulfonamide drugs, sympathectomy.
Pregnancy (1 trimester), lactation.
Lisinopril, generally well tolerated. Of the side effects are most common hypokalemia, dyspepsia, at least - confusion, convulsions, easing the processes of thinking, fatigue, irritability, muscle spasms; dry mouth, feeling of thirst, nausea, or vomiting; arrhythmic heartbeat, weak pulse. Rarely - agranulocytosis, allergic reaction, cholecystitis or pancreatitis, liver function abnormalities (yellow skin or sclera), thrombocytopenia (unusual bleeding, tarry stools, blood in the urine or feces, petechiae on the skin). Sometimes - anorexia, decreased sexual function, diarrhea, orthostatic hypotension, photosensitivity.
Dosing and Administration
Lisinopril is prescribed orally during or after a meal. The dose is determined individually. Single dose while taking the drug as a diuretic from 0.025 g to 0.2 g In mild cases, appoint 0,025 g - 0.05 g (1-2 tablets) per day, in more severe cases - to 0.1 grams per day.
Prolonged treatment is sometimes prescribed medication 2-3 times a week. The duration of each course and the total duration of the reception depends on the nature and severity of the pathological process, the effect of portability.
In hypertensive appoint 0.025-0.05 g (1-2 tablets) per day, as a rule, together with antihypertensive drugs. In glaucoma, take 0,025 grams per day.
Kids appointed interior in a daily dose of 1-2 mg / kg body weight once or in two installments. To prevent the formation of stones in the kidneys - 50 mg twice a day.
With diabetes insipidus in the beginning of treatment the daily dose is 100 mg in 2-4 receptions, further dose reduction is possible. Correcting the dose depending on the patient.
There may be violations of water-electrolyte balance, nausea, weakness, dizziness, worsening of gout. In case of overdose, symptomatic treatment with monitoring the concentration of salts and renal function. With hypokalemia appoint asparkam, potassium chloride; when hyperchloraemic alkalosis administered isotonic sodium chloride solution, for smaller manifestations of gout allopurinol administered.
Interactions with other drugs
Lisinopril may reduce renal clearance of amantadine, which leads to increasing the concentration of the latter in the blood plasma and increased probability of toxic effects of amantadine. With simultaneous use of Lisinopril and amiodarone may increase the risk of cardiac arrhythmias associated with hypokalemia. With simultaneous use of Lisinopril and anticoagulants (coumarin derivatives or indandiona) may be reduced anticoagulant properties of the latter, and may also increase the synthesis of clotting factors that require adjustment of doses. The drug can increase blood glucose levels, which requires adjustment of insulin doses and oral antidiabetics. Nonsteroidal anti-inflammatory drugs, especially indomethacin may reduce the antihypertensive and diuretic effect of Lisinopril, which requires careful monitoring of the patient. NSAIDs increase the risk of renal failure, while the use of Lisinopril. The simultaneous use of high doses of Lisinopril formulations containing calcium can lead to hypercalcemia. With simultaneous use of Lisinopril and digitalis drugs increases the likelihood of toxic action of digitalis associated with hypokalemia and hypomagnesemia. With simultaneous use of Lisinopril with dopamine may increase the diuretic and natriuretic action. With simultaneous use of Lisinopril and tools that cause hypokalemia, there is a risk of severe hypokalemia, which requires monitoring the concentration of potassium in the blood serum and activity of the heart, as well as additional prescribing potassium. With simultaneous use of Lisinopril with antihypertensive drugs may increase the hypotensive effect that requires an adjustment of doses. The simultaneous use of Lisinopril with lithium is not recommended due to the possibility of increasing the toxic effects of lithium and the risk of developing nephrotic effects.
Cautions when taking
Drug treatment should be supervised by a physician. Doses throughout the day should be distributed so as to minimize discomfort associated with diuretic drugs (except for diabetes insipidus). The habit of taking Lisinopril at one and the same time helps to stick to the recommended mode and patterns of use. If you miss a dose, you should take it as soon as possible. Do not take the drug if it is almost time for your next dose, ie not double the dose. In the application of Lisinopril as antihypertensive agent, it is important to follow a diet, limit the intake of sodium and / or reduce body weight. Patients with hypersensitivity to sulfonamide drugs, bumetanide, furosemide, or carbonic anhydrase inhibitors may be sensitive to Lisinopril. Elderly patients may be more sensitive to the drug, which requires adjustment of doses. Need to be careful in the selection of doses for patients with gout (due to the ability of Lisinopril raise uric acid levels), and for patients with severe coronary or cerebral atherosclerosis. In diabetes, hyperglycemia can occur, especially with hypokalemia. In renal insufficiency must be carefully monitored for electrolyte balance and creatinine clearance. Severe loss of water and electrolytes during prolonged treatment with high doses of Lisinopril may exacerbate the symptoms of kidney failure.
During pregnancy, the indications for use of the drug should be carefully justified. Lisinopril should not be prescribed for eclampsia, pre-eclampsia or edema of any origin during pregnancy. Due to the presence of the drug in the photosensitizing properties to avoid excessive sun exposure. The patient can not feel the symptoms of hypertension, so it is important to take the drug even in good health. Not recommended to prescribe the drug for lipid metabolism disorders, hypercholesterolemia, hypertriglyceridemia, hyponatremia.